ELIZA

return kwic search for associated with out of >500 occurrences
579792 occurrences (No.16 in the rank) during 5 years in the PubMed. [no cache] 500 found

204) After MCAO, reduced brain edema and inflammatory responses were associated with altered levels of angiogenic factors and cytokines in preconditioned brains.

--- ABSTRACT ---

PMID:24005261 DOI:10.1007/s00429-013-0632-5

2015 Brain structure & function

* Extracellular signal-regulated kinase1/2-dependent changes in tight junctions after ischemic preconditioning contributes to tolerance induction after ischemic stroke.

- Less disruption of the blood-brain barrier (BBB) after severe ischemic stroke is one of the beneficial outcomes of ischemic preconditioning (IP). However, the effect of IP on tight junctions (TJs), which regulate paracellular permeability of the BBB, is not well understood. In the present study, we examined IP-induced changes in TJs before and after middle cerebral artery occlusion (MCAO) in mice, and the association between changes in TJs and tolerance to a subsequent insult. After IP, we found decreased levels of transmembrane TJ proteins occludin and claudin-5, and widened gaps of TJs with perivascular swelling at the ultrastructural level in the brain. An inflammatory response was also observed. These changes were reversed by inhibition of extracellular signal-regulated kinase1/2 (ERK1/2) via the specific ERK1/2 inhibitor U0126. After MCAO, reduced brain edema and inflammatory responses were associated with altered levels of angiogenic factors and cytokines in preconditioned brains. Pretreatment with U0126 reversed the neuroprotective effects of IP against MCAO. These findings suggest that ERK1/2 activation has a pivotal role in IP-induced changes in TJs and inflammatory response, which serve to protect against BBB breakdown and inflammation after ischemic stroke.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to associated with]

(1)51 the	(16)4 significantly	(31)2 being	(46)2 less
(2)31 a	(17)3 FIQ	(32)2 diabetes	(47)2 many
(3)12 increased	(18)3 cancer	(33)2 different	(48)2 maternal
(4)12 lower	(19)3 chronic	(34)2 early	(49)2 nephrolithiasis
(5)9 higher	(20)3 more	(35)2 excessive	(50)2 normal
(6)8 an	(21)3 other	(36)2 faster	(51)2 parenchymal
(7)7 decreased	(22)3 perceived	(37)2 female	(52)2 physical
(8)6 poor	(23)3 shorter	(38)2 gene	(53)2 positive
(9)5 both	(24)3 smoking	(39)2 genetic	(54)2 reductions
(10)5 greater	(25)3 specific	(40)2 good	(55)2 stress
(11)4 adverse	(26)2 JS	(41)2 having	(56)2 them
(12)4 negative	(27)2 SWD	(42)2 high	(57)2 this
(13)4 poorer	(28)2 alterations	(43)2 implementation	(58)2 undernutrition
(14)4 reduced	(29)2 altered	(44)2 improvements	(59)2 very
(15)4 significant	(30)2 any	(45)2 internalizing

add keyword

--- WordNet output for associated --- Overview of verb associate The verb associate has 3 senses (first 3 from tagged texts) 1. (25) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (3) consort, associate, affiliate, assort -- (keep company with; hang out with; "He associates with strange people"; "She affiliates with her colleagues") 3. (1) consociate, associate -- (bring or come into association or action; "The churches consociated to fight their dissolution") --- WordNet end ---