ELIZA

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315808 occurrences (No.69 in the rank) during 5 years in the PubMed. [no cache] 500 found

245) We report an extremely rare case of familial breast cancer with deleterious germline mutations in both BRCA1 and BRCA2 genes, of which, to date, no such case has been reported among Japanese breast/ovarian cancer patients.

--- ABSTRACT ---

PMID:23242612 DOI:10.1007/s12282-012-0432-4

2015 Breast cancer (Tokyo, Japan)

* A case of familial breast cancer with double heterozygosity for BRCA1 and BRCA2 genes.

- We report an extremely rare case of familial breast cancer with deleterious germline mutations in both BRCA1 and BRCA2 genes, of which, to date, no such case has been reported among Japanese breast/ovarian cancer patients. Genetic testing of the family members indicated that the same double heterozygosity for BRCA1 and BRCA2 genes was transmitted to the paternal cousin, and the same BRCA2 mutation to the younger sister with bilateral breast cancer, younger brother with stomach cancer, and proband's son and daughter without cancer. Immunohistochemical analysis of BRCA protein expression was performed using breast cancer tissues from the proband with double heterozygosity for BRCA1 and BRCA2 genes and from her sibling without BRCA1 mutation but with BRCA2 mutation. There was no staining of either BRCA in the proband and no staining of BRCA2 in the sibling.

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(1)76 the	(16)4 four	(31)3 them	(46)2 island
(2)19 women	(17)4 immigrant	(32)3 these,	(47)2 mainstream
(3)10 children	(18)4 people	(33)2 10	(48)2 male
(4)9 Chinese	(19)4 these	(34)2 EB	(49)2 marine
(5)8 different	(20)4 workers	(35)2 HIV-positive	(50)2 migrant
(6)8 men	(21)4 young	(36)2 Italian	(51)2 mothers
(7)8 patients	(22)3 adult	(37)2 Japanese	(52)2 nondaily
(8)6 this	(23)3 diabetic	(38)2 Latinos	(53)2 other
(9)6 those	(24)3 elderly	(39)2 S	(54)2 pregnant
(10)5 Latino	(25)3 individuals	(40)2 adolescent	(55)2 schoolchildren
(11)5 a	(26)3 nursing	(41)2 alcoholics	(56)2 species
(12)5 all	(27)3 older	(42)2 areas	(57)2 undergraduate
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--- WordNet output for among --- =>に混じって, に共通して, のうちで, が一緒で, の間に --- WordNet end ---