ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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475194 occurrences (No.33 in the rank) during 5 years in the PubMed. [cache]
328) It is concluded that diazepam and phenobarbitone exhibited prominent AchE attenuation apart from their well-established antidepressant activity, which could be more useful in related diseased conditions.
* Attenuation of erythrocytic actylcholinesterase by antidepressants: evidence in an in vitro experiment.
- The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. The experimental designed was based on Michaelis-Menten parameters (apparent Michaelis constant (aKm) and apparent maximum velocity (aVm)) that estimate inhibition (%) as well as the type of inhibition (mechanism). The results showed marked inhibition of AchE by diazepam and the values of aKm and aVm were 65.5% and 52.63%, respectively. These values suggested a competitive type of antagonism for diazepam. Similar trend of antagonism was shown by phenobarbitone when it was subjected to the challenge of AchE with aKm and aVm values of 51.99% and 71.80%, respectively. It is concluded that diazepam and phenobarbitone exhibited prominent AchE attenuation apart from their well-established antidepressant activity, which could be more useful in related diseased conditions.
=>活動, 活躍, 働き, 動き, 活気
Overview of noun activity
The noun activity has 6 senses (first 3 from tagged texts)
1. (43) activity -- (any specific behavior; "they avoided all recreational activity")
2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is
out of action")
3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes
place in the body; "respiratory activity")
4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction;
"catalytic activity")
5. natural process, natural action, action, activity -- (a process existing in or produced by nature
(rather than by the intent of human beings); "the action of natural forces"; "volcanic activity")
6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically;
"the level of activity declines with age")
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