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return kwic search for activity out of >500 occurrences
475194 occurrences (No.33 in the rank) during 5 years in the PubMed. [no cache] 500 found
229) Locomotor activity was monitored with photobeam cell detectors, and accumbens shell/core microdialysate dopamine levels were monitored by high-performance liquid chromatography with electrochemical detection.
--- ABSTRACT ---
PMID:23910902 DOI:10.1111/adb.12080
2015 Addiction biology
* Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice.
- The endocannabinoid system has been implicated in the development of synaptic plasticity induced by several drugs abused by humans, including cocaine. However, there remains some debate about the involvement of cannabinoid receptors/ligands in cocaine-induced plasticity and corresponding behavioral actions. Here, we show that a single cocaine injection in Swiss-Webster mice produces behavioral and neurochemical alterations that are under the control of the endocannabinoid system. This plasticity may be the initial basis for changes in brain processes leading from recreational use of cocaine to its abuse and ultimately to dependence. Locomotor activity was monitored with photobeam cell detectors, and accumbens shell/core microdialysate dopamine levels were monitored by high-performance liquid chromatography with electrochemical detection. Development of single-trial cocaine-induced behavioral sensitization, measured as increased distance traveled in sensitized mice compared to control mice, was paralleled by a larger stimulation of extracellular dopamine levels in the core but not the shell of the nucleus accumbens. Both the behavioral and neurochemical effects were reversed by CB1 receptor blockade produced by rimonabant pre-treatments. Further, both behavioral and neurochemical cocaine sensitization were facilitated by pharmacological blockade of endocannabinoid metabolism, achieved by inhibiting the fatty acid amide hydrolase enzyme. In conclusion, our results suggest that a single unconditioned exposure to cocaine produces sensitization through neuronal alterations that require regionally specific release of endocannabinoids. Further, the present results suggest that endocannabinoids play a primary role from the earliest stage of cocaine use, mediating the inception of long-term brain-adaptive responses, shaping central pathways and likely increasing vulnerability to stimulant abuse disorders.
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(1)70 of (13)6 patterns (25)3 but (37)2 functional
(2)54 *null* (14)5 may (26)3 changes (38)2 increased
(3)49 and (15)5 using (27)3 for (39)2 induces
(4)45 in (16)5 with (28)3 measured (40)2 level
(5)17 was (17)4 at (29)3 through (41)2 or
(6)11 against (18)4 levels (30)2 Questionnaire (42)2 over
(7)10 during (19)4 on (31)2 after (43)2 promotion
(8)9 (PA) (20)4 which (32)2 between (44)2 resumption
(9)8 is (21)4 while (33)2 calcium (45)2 than
(10)7 to (22)3 among (34)2 compared (46)2 that
(11)7 were (23)3 are (35)2 decreased (47)2 via
(12)6 by (24)3 as (36)2 diary (48)2 when

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--- WordNet output for activity --- =>活動, 活躍, 働き, 動き, 活気 Overview of noun activity The noun activity has 6 senses (first 3 from tagged texts) 1. (43) activity -- (any specific behavior; "they avoided all recreational activity") 2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is out of action") 3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes place in the body; "respiratory activity") 4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity") 5. natural process, natural action, action, activity -- (a process existing in or produced by nature (rather than by the intent of human beings); "the action of natural forces"; "volcanic activity") 6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically; "the level of activity declines with age") --- WordNet end ---