* Antimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsions.
- Antimicrobial photodynamic therapy represents an alternative method of killing resistant pathogens. Efforts have been made to develop delivery systems for hydrophobic drugs to improve the photokilling. This study evaluated the photodynamic effect of chloro-aluminum phthalocyanine (ClAlPc) encapsulated in nanoemulsions (NE) on methicillin-susceptible and methicillin-resistant Staphylococcus aureus suspensions and biofilms. Suspensions and biofilms were treated with different delivery systems containing ClAlPc. After the pre-incubation period, the drug was washed-out and irradiation was performed with LED source (660 ± 3 nm). Negative control samples were not exposed to ClAlPc or light. For the suspensions, colonies were counted (colony-forming units per milliliter (CFU/mL)). The metabolic activity of S. aureus suspensions and biofilms were evaluated by the XTT assay. The efficiency was dependent on the delivery system, superficial load and light dose. Cationic NE-ClAlPc and free-ClAlPc caused photokilling of the both strains of S. aureus. For biofilms, cationic NE-ClAlPc reduced cell metabolism by 80 and 73% of susceptible and resistant strains, respectively. Although anionic NE-ClAlPc caused a significant CFU/ml reduction for MSSA and MRSA, it was not capable of reducing MRSA biofilm metabolism. This therapy may represent an alternative treatment for eradicating resistant strains.
=>活動, 活躍, 働き, 動き, 活気
Overview of noun activity
The noun activity has 6 senses (first 3 from tagged texts)
1. (43) activity -- (any specific behavior; "they avoided all recreational activity")
2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is
out of action")
3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes
place in the body; "respiratory activity")
4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction;
"catalytic activity")
5. natural process, natural action, action, activity -- (a process existing in or produced by nature
(rather than by the intent of human beings); "the action of natural forces"; "volcanic activity")
6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically;
"the level of activity declines with age")
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