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return kwic search for activity out of >500 occurrences
475194 occurrences (No.33 in the rank) during 5 years in the PubMed. [no cache] 500 found
16) To gain insight into the biological activity of P.
--- ABSTRACT ---
PMID:23892478 DOI:10.1007/s10616-013-9590-2
2015 Cytotechnology
* Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death.
- Nitensidine A is a guanidine alkaloid isolated from Pterogyne nitens, a common plant in South America. To gain insight into the biological activity of P. nitens-produced compounds, we examined herein their biological effects on osteoclasts, multinucleated giant cells that regulate bone metabolism by resorbing bone. Among four guanidine alkaloids (i.e., galegine, nitensidine A, pterogynidine, and pterogynine), nitensidine A and pterogynine exhibited anti-osteoclastic effects at 10 μM by reducing the number of osteoclasts on the culture plate whereas galegine and pterogynidine did not. The anti-osteoclastic activities of nitensidine A and pterogynine were exerted in a concentration-dependent manner, whereas nitensidine A exhibited an approximate threefold stronger effect than pterogynine (IC50 values: nitensidine A, 0.93 ± 0.024 μM; pterogynine, 2.7 ± 0.40 μM). In the present study, the anti-osteoclastic effects of two synthetic nitensidine A derivatives (nitensidine AT and AU) were also examined to gain insight into the structural features of nitensidine A that exert an anti-osteoclastic effect. The anti-osteoclastic effect of nitensidine A was greatly reduced by substituting the imino nitrogen atom in nitensidine A with sulfur or oxygen. According to the differences in chemical structures and anti-osteoclastic effects of the four guanidine alkaloids and the two synthetic nitensidine A derivatives, it is suggested that the number, binding site, and polymerization degree of isoprenyl moiety in the guanidine alkaloids and the imino nitrogen atom cooperatively contribute to their anti-osteoclastic effects.
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(1)70 of (13)6 patterns (25)3 but (37)2 functional
(2)54 *null* (14)5 may (26)3 changes (38)2 increased
(3)49 and (15)5 using (27)3 for (39)2 induces
(4)45 in (16)5 with (28)3 measured (40)2 level
(5)17 was (17)4 at (29)3 through (41)2 or
(6)11 against (18)4 levels (30)2 Questionnaire (42)2 over
(7)10 during (19)4 on (31)2 after (43)2 promotion
(8)9 (PA) (20)4 which (32)2 between (44)2 resumption
(9)8 is (21)4 while (33)2 calcium (45)2 than
(10)7 to (22)3 among (34)2 compared (46)2 that
(11)7 were (23)3 are (35)2 decreased (47)2 via
(12)6 by (24)3 as (36)2 diary (48)2 when

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--- WordNet output for activity --- =>活動, 活躍, 働き, 動き, 活気 Overview of noun activity The noun activity has 6 senses (first 3 from tagged texts) 1. (43) activity -- (any specific behavior; "they avoided all recreational activity") 2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is out of action") 3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes place in the body; "respiratory activity") 4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity") 5. natural process, natural action, action, activity -- (a process existing in or produced by nature (rather than by the intent of human beings); "the action of natural forces"; "volcanic activity") 6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically; "the level of activity declines with age") --- WordNet end ---