ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for acid out of >500 occurrences
272943 occurrences (No.93 in the rank) during 5 years in the PubMed. [no cache] 500 found
24) The hydrogels are tested as pH-responsive carriers in in vitro release studies of folic acid and thiamine, two model drugs easily degraded by oxidative conditions simulated by UV irradiation and t-butyl hydroperoxide treatment, respectively.
--- ABSTRACT ---
PMID:24289106 DOI:10.3109/10837450.2013.862261
2015 Pharmaceutical development and technology
* Flavonoid-based pH-responsive hydrogels as carrier of unstable drugs in oxidative conditions.
- In this study, pH-responsive hydrogels, synthesized by the coupling reaction of polyacrylic acid and catechin, are proposed as carriers of oxidable drugs toward the GI tract. The presence of polyphenolic moieties in the network gives the polymers properties suitable for the release of unstable drugs in oxidative conditions. The characterization of the hydrogels is obtained by means of morphological and physico-chemical analyses, antioxidant assays and evaluation of the swelling behavior in media simulating the gastric (pH 1.0) and the intestinal (pH 7.4) tracts. The hydrogels are tested as pH-responsive carriers in in vitro release studies of folic acid and thiamine, two model drugs easily degraded by oxidative conditions simulated by UV irradiation and t-butyl hydroperoxide treatment, respectively. Results show that catechin-based carriers are able to control the release of drugs at different pH values, giving a remarkable improvement in the stability of the therapeutics.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to acid]
(1)29 and (20)4 treatment (39)2 (FA) (58)2 from
(2)15 *null* (21)3 (AA) (40)2 (PA) (59)2 hydrolysis
(3)11 in (22)3 (ALA) (41)2 (PLGA) (60)2 interactions
(4)10 phenethyl (23)3 (GABA) (42)2 (PLGA), (61)2 may
(5)10 phosphatase (24)3 (NEFA) (43)2 (SA) (62)2 nanoparticles
(6)9 is (25)3 changes (44)2 (SLA) (63)2 peptide
(7)8 was (26)3 decarboxylase (45)2 (TA) (64)2 proteins
(8)6 (HA) (27)3 etching (46)2 (TCA) (65)2 racemization
(9)6 reactive (28)3 levels (47)2 A (66)2 ratio
(10)5 as (29)3 metabolism (48)2 BSA (67)2 residues
(11)5 bacteria (30)3 on (49)2 Ig-superfamily (68)2 substances
(12)5 group (31)3 protein (50)2 Schiff (69)2 suppressive
(13)5 or (32)3 sequence (51)2 biosynthesis (70)2 synthetase
(14)5 synthesis (33)3 sequences (52)2 by (71)2 the
(15)5 to (34)3 status (53)2 changes, (72)2 therapy
(16)4 binding (35)3 were (54)2 composition (73)2 vitamin
(17)4 derivatives (36)2 (DHA) (55)2 contents
(18)4 for (37)2 (EDTA) (56)2 cycle
(19)4 solution (38)2 (EPA) (57)2 extract

add keyword

--- WordNet output for acid --- =>1.酸っぱい, 2.辛辣な, 3.酸, 4.《俗語》麻薬, LSD Overview of noun acid The noun acid has 2 senses (first 1 from tagged texts) 1. (4) acid -- (any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt) 2. acid, back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen -- (street name for lysergic acid diethylamide) Overview of adj acid The adj acid has 3 senses (first 1 from tagged texts) 1. (1) acerb, acerbic, acid, acrid, bitter, blistering, caustic, sulfurous, sulphurous, virulent, vitriolic -- (harsh or corrosive in tone; "an acerbic tone piercing otherwise flowery prose"; "a barrage of acid comments"; "her acrid remarks make her many enemies"; "bitter words"; "blistering criticism"; "caustic jokes about political assassination, talk-show hosts and medical ethics"; "a sulfurous denunciation"; "a vitriolic critique") 2. acidic, acid, acidulent, acidulous -- (being sour to the taste) 3. acid -- (having the characteristics of an acid; "an acid reaction") --- WordNet end ---