* Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery.
- The purpose of this study was to investigate the feasibility of entrapping water-insoluble drug itraconazole into solid lipid nanoparticles (SLNs) for topical ocular delivery. The drug-loaded SLNs were prepared from stearic acid and palmitic acid using different concentrations of polyvinyl alcohol employed as emulsifier. SLNs were prepared by the melt-emulsion sonication and low temperature-solidification method and characterized for particle size, zeta potential, drug loading and drug entrapment efficiency. The mean particle size of SLNs prepared with stearic acid ranged from 139 to 199 nm, while the SLNs prepared with palmitic acid had particle size in the range of 126-160 nm. The SLNs were spherical in shape. Stearic acid-SLNs showed higher entrapment of drug compared with palmitic acid-SLNs. Differential scanning calorimetry (DSC) and X-ray diffraction measurements showed decrease in crystallinity of drug in the SLN formulations. The modified Franz-diffusion cell and freshly excised goat corneas were used to test drug corneal permeability. Permeation of itraconazole from stearic acid-SLNs was higher than that obtained with palmitic acid-SLNs. The SLNs showed clear zone of inhibition against Aspergillus flavus indicating antimicrobial efficacy of formulations.
=>1.酸っぱい, 2.辛辣な, 3.酸, 4.《俗語》麻薬, LSD
Overview of noun acid
The noun acid has 2 senses (first 1 from tagged texts)
1. (4) acid -- (any of various water-soluble compounds having a sour taste and capable of turning
litmus red and reacting with a base to form a salt)
2. acid, back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds,
pane, superman, window pane, Zen -- (street name for lysergic acid diethylamide)
Overview of adj acid
The adj acid has 3 senses (first 1 from tagged texts)
1. (1) acerb, acerbic, acid, acrid, bitter, blistering, caustic, sulfurous, sulphurous, virulent,
vitriolic -- (harsh or corrosive in tone; "an acerbic tone piercing otherwise flowery prose"; "a
barrage of acid comments"; "her acrid remarks make her many enemies"; "bitter words"; "blistering
criticism"; "caustic jokes about political assassination, talk-show hosts and medical ethics"; "a
sulfurous denunciation"; "a vitriolic critique")
2. acidic, acid, acidulent, acidulous -- (being sour to the taste)
3. acid -- (having the characteristics of an acid; "an acid reaction")
--- WordNet end ---