2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
* Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia.
- No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes.
=>1.その場所で, そこに(で), そこへ, 2.〜がある, その場所で
Overview of noun there
The noun there has 1 sense (no senses from tagged texts)
1. there -- (a location other than here; that place; "you can take it from there")
Overview of adv there
The adv there has 3 senses (first 3 from tagged texts)
1. (181) there, at that place, in that location -- (in or at that place; "they have lived there for
years"; "it's not there"; "that man there")
2. (6) there, in that respect, on that point -- (in that matter; "I agree with you there")
3. (2) there, thither -- (to or toward that place; away from the speaker; "go there around noon!")
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