ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [cache]
12) Notably, Sca-1 was found to be a direct transcriptional target of Stat3 in keratinocytes.
--- ABSTRACT ---
PMID:24038534 DOI:10.1002/mc.22080
2015 Molecular carcinogenesis
* Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.
- STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation and migration as well as in cancer development. In the present study, we examined the impact of constitutive activation of Stat3 on behavior of keratinocytes, including keratinocyte stem cells (KSC) in vivo. BK5.Stat3C transgenic (Tg) mice, which express a constitutively active form of Stat3 (Stat3C) in the basal layer of the epidermis and in the bulge region KSCs exhibited a significantly reduced number of CD34+/α6 integrin+ cells compared to non-transgenic (NTg) littermates. There was a concomitant increase in the Lgr-6, Lrig-1, and Sca-1 populations in the Tg mice in contrast to the CD34 and Keratin-15 positive population. In addition, increased expression of c-myc, β-catenin, and epithelial-mesenchymal transition (EMT)-related genes as well as decreased expression of α6-integrin was observed in the hair follicles of Tg mice. Notably, Sca-1 was found to be a direct transcriptional target of Stat3 in keratinocytes. The current data suggest that elevated Stat3 activity leads to depletion of hair follicle KSCs along with a concomitant increase of stem/progenitor cells above the bulge region. Overall, the current data indicate that Stat3 plays an important role in keratinocyte stem/progenitor cell homeostasis.
--- ABSTRACT END ---
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--- WordNet output for found --- =>設立する, 基礎づける Overview of noun found The noun found has 1 sense (first 1 from tagged texts) 1. (1) found -- (food and lodging provided in addition to money; "they worked for $30 and found") Overview of verb found The verb found has 3 senses (first 2 from tagged texts) 1. (9) establish, set up, found, launch -- (set up or found; "She set up a literacy program") 2. (4) establish, found, plant, constitute, institute -- (set up or lay the groundwork for; "establish a new department") 3. establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") Overview of verb find The verb find has 16 senses (first 13 from tagged texts) 1. (159) find, happen, chance, bump, encounter -- (come upon, as if by accident; meet with; "We find this idea in Plato"; "I happened upon the most wonderful bakery not very far from here"; "She chanced upon an interesting book in the bookstore the other day") 2. (141) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 3. (86) find, regain -- (come upon after searching; find the location of something that was missed or lost; "Did you find your glasses?"; "I cannot find my gloves!") 4. (57) determine, find, find out, ascertain -- (establish after a calculation, investigation, experiment, survey, or study; "find the product of two numbers"; "The physicist who found the elusive particle won the Nobel Prize") 5. (57) find, feel -- (come to believe on the basis of emotion, intuitions, or indefinite grounds; "I feel that he doesn't like me"; "I find him to be obnoxious"; "I found the movie rather entertaining") 6. (45) witness, find, see -- (perceive or be contemporaneous with; "We found Republicans winning the offices"; "You'll see a lot of cheating in this school"; "The 1960's saw the rebellion of the younger generation against established traditions"; "I want to see results") 7. (41) line up, get hold, come up, find -- (get something or somebody for a specific purpose; "I found this gadget that will serve as a bottle opener"; "I got hold of these tools to fix our plumbing"; "The chairman got hold of a secretary on Friday night to type the urgent letter") 8. (34) discover, find -- (make a discovery, make a new finding; "Roentgen discovered X-rays"; "Physicists believe they found a new elementary particle") 9. (29) discover, find -- (make a discovery; "She found that he had lied to her"; "The story is false, so far as I can discover") 10. (16) find -- (obtain through effort or management; "She found the time and energy to take care of her aging parents"; "We found the money to send our sons to college") 11. (16) rule, find -- (decide on and make a declaration about; "find someone guilty") 12. (13) receive, get, find, obtain, incur -- (receive a specified treatment (abstract); "These aspects of civilization do not find expression or receive an interpretation"; "His movie received a good review"; "I got nothing but trouble for my good intentions") 13. (11) find -- (perceive oneself to be in a certain condition or place; "I found myself in a difficult situation"; "When he woke up, he found himself in a hospital room") 14. recover, retrieve, find, regain -- (get or find back; recover the use of; "She regained control of herself"; "She found her voice and replied quickly") 15. find -- (succeed in reaching; arrive at; "The arrow found its mark") 16. find oneself, find -- (accept and make use of one's personality, abilities, and situation; "My son went to Berkeley to find himself") Overview of adj found The adj found has 1 sense (first 1 from tagged texts) 1. (1) found -- (come upon unexpectedly or after searching; "found art"; "the lost-and-found department") --- WordNet end ---